Clin Infect Dis. 2010 May 1;50(9):1316-21.
Incidence of malignancies in HIV-infected patients and
prognostic role of current CD4 cell count: evidence from a large
Italian cohort study.
Prosperi MC, Cozzi-Lepri A, Castagna A, Mussini C, Murri R,
Giacometti A, Torti C, Costantini A, Narciso P, Ghinelli F,
Antinori A, d'Arminio Monforte A; Icona Foundation Study Group.
Collaborators (143)Moroni M, Antinori A, Carosi G, Cauda R,
d'Arminio Monforte A, Di Perri G, Galli M, Ghinelli F, Iardino
R, Ippolito G, Lazzarin A, Mazzotta F, Panebianco R, Pastore G,
Perno CF, Ammassari A, Antinori A, Arici C, Balotta C, Bonfanti
P, Capobianchi MR, Castagna A, Ceccherini-Silberstein F,
Cozzi-Lepri A, d'Arminio Monforte A, De Luca A, Gervasoni C,
Girardi E, Lo Caputo S, Maggiolo F, Murri R, Mussini C, Puoti M,
Torti C, Cozzi-Lepri A, Fanti I, Formenti T, Prosperi MC,
Montroni M, Giacometti A, Costantini A, Riva A, Tirelli U,
Martellotta F, Pastore G, Ladisa N, Pierri A, Suter F, Maggiolo
F, Borderi M, Verucchi G, Piergentili B, Carosi G, Cristini G,
Torti C, Minardi C, Bertelli D, Quirino D, Abeli C, Manconi PE,
Piano P, Vecchiet J, Falasca K, Carnevale G, Lorenzotti S,
Ghinelli F, Sighinolfi L, Leoncini F, Mazzotta F, Pozzi M, Lo
Caputo S, Pagano G, Cassola G, Viscoli G, Alessandrini A,
Piscopo R, Mazzarello G, Soscia F, Tacconi L, Orani A, Rossotti
R, Tommasi D, Congedo P, Chiodera A, Castelli P, Galli M,
Lazzarin A, Rizzardini G, Schlacht I, d'Arminio Monforte A,
Ridolfo AL, Foschi A, Castagna A, Salpietro S, Merli S, Melzi S,
Moioli MC, Cicconi P, Formenti T, Esposito R, Mussini C, Gori A,
Fiorino M, Abrescia N, Chirianni A, Izzo CM, De Marco M,
Viglietti R, Manzillo E, Ferrari C, Pizzaferri P, Baldelli F,
Belfiori B, Magnani G, Ursitti MA, Arlotti M, Ortolani P, Cauda
R, Andreoni M, Antinori A, Antonucci G, Narciso P, Tozzi V,
Vullo V, De Luca A, Zaccarelli M, Acinapura R, De Longis P,
Trotta MP, Calbi M, Gallo L, Miccoli A, Carletti F, Mura MS,
Madeddu G, Caramello P, Di Perri G, Orofino GC, Sciandra M,
Raise E, Ebo F, Pellizzer G, Buonfrate D.
Istituto di Clinica delle Malattie Infettive, Università
Cattolica del Sacro Cuore, Rome, Italy. ahnven@yahoo.it
Abstract
The incidence of and predictors of acquired immunodeficiency
syndrome-defining malignancies (ADMs) and non-ADM (NADMs) were
evaluated in a large Italian cohort. The incidence of ADM and
NADM was 5.0 cases per 1000 person-years of follow-up (95%
confidence interval, 4.3-5.8 cases per 1000 person-years of
follow-up) and 2.4 cases per 1000 person-years of follow-up (95%
confidence interval, 1.9-3.1 cases per 1000 person-years of
follow-up), respectively. Lower current CD4 cell count was an
independent predictor of developing malignancies, with the
association being stronger for ADM than for NADM.