- 168: AIDS Patient Care STDS. 2008 Apr;22(4):291-9
Self-reported sexual dysfunction is frequent among HIV-infected persons and is associated with suboptimal adherence to antiretrovirals.Trotta MP, Ammassari A, Murri R, Marconi P, Zaccarelli M, Cozzi-Lepri A, Acinapura R, Abrescia N, De Longis P, Tozzi V, Scalzini A, Vullo V, Boumis E, Nasta P, Monforte A, Antinori A; AdICoNA and AdeSpall Study Group.
Collaborators (68)
Tirelli U, Di Gennaro G, Carosi G, Minardi C, Manconi PE, Piano P, Vecchiett J, Dalessandro M, Mazzotta F, Lo Caputo S, Soscia F, Tacconi L, Scasso A, Vincenti A, Scalzini A, Palvarini L, Moroni M, d'Arminio Monforte A, Repetto D, Esposito R, Mussini C, Piazza M, Abrescia N, Izzo MC, De Marco M, Manzillo E, Nappa S, Alberici F, Ruggeri A, Baldelli F, Camanni G, Acinapura R, Ammassari A, Antinori A, Antonucci G, Ciardi M, De Longis P, D'Offizi G, Ippolito G, Lichtner M, Marconi P, Murri R, Narciso P, Boumis E, Petrosillo N, Pezzotti P, Santopadre P, Trotta MP, Vullo V, Zaccarelli M, Caramello P, Orofino GC, Cozzi-Lepri A, Wu AW, Antinori A, Ammassari A, Bonfigli S, Boumis E, De Longis P, D'Offizi GP, Liuzzi G, Marconi P, Narciso P, Sette P, Tozzi V, Trotta MP, Visco Comandini U, Zaccarelli M.
Istituto Nazionale per le Malattie Infettive, L Spallanzani IRCCS, Rome, Italy. trotta@inmi.it
Increased occurrence of sexual dysfunction (SD) among patients treated with highly active antiretroviral therapy (HAART) has been reported. To assess prevalence of self-reported SD and to identify factors related to this alteration with special focus to its relationship with adherence behavior, we conducted an intercohort analysis among HIV-infected persons treated with HAART. In an anonymous questionnaire investigating HAART nonadherence, patients were asked to report the occurrence of dysfunction in sexual activity over the previous 4 weeks. Among 612 participants, 125 (21%) reported some degree of SD. "Moderate"/"severe" alterations were reported in 6% and were independently associated with self-reported worsening of viro-immunological parameters (OR 3.90; 95% CI 1.08-14.18), higher symptom score (OR 1.13; 95% CI 1.05-1.22), and reporting abnormal fat accumulation (OR 4.33; 95% CI 1.55-12.11). Furthermore, nonadherent persons had an increased risk of SD (OR 3.44; 95% CI 1.30-9.08). In conclusion, patients' perceived SD represents a relevant problem for HIV-infected persons treated with antiretrovirals and is strongly associated with suboptimal HAART adherence.